Muscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential Roles of Lipolysis - PubMed
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- #inflammaging
- #muscle-adipose aging
- #lipolysis
- Muscle-adipose aging dynamics differ substantially across ethnically diverse populations, with Taiwanese men showing steeper declines in muscle mass but higher muscle-to-fat ratios.
- Inflammaging patterns, including a 90% increase in CRP and 20-24% decline in IGF-1 from ages 45 to 79, were consistent across UK, US, and Taiwanese cohorts.
- BMI-adjusted muscle mass measurements show greater age-related deterioration than height-adjusted measures, suggesting conventional methods may mask sarcopenic progression.
- Adiposity peaks earlier in Western populations (55-59 years) compared to Taiwanese adults (60-64 years), followed by late-life declines indicative of differential lipolytic activation.
- Increased ketone body concentrations with age in the UK cohort suggest higher fat oxidation in older adults.
- Metabolic efficiency, rather than absolute tissue quantity, emerges as a key determinant of healthy aging across populations.