The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue - PubMed
2 hours ago
- #TRIM21
- #nuclear pore degradation
- #molecular glue
- PRLX-93936 (PRLX) is a molecular glue that changes TRIM21's substrate specificity, causing it to bind NUP98 and degrade nuclear pore complexes.
- The ternary complex assembly relies on a composite surface formed by TRIM21 and the small molecule, with few direct contacts to NUP98, explaining how diverse ligands can induce degradation.
- An enhanced molecular glue, MAN-021, was discovered, and its structure described, aiding rational development of next-generation small molecules.