Time-resolved immune dynamics in rheumatoid arthritis under methotrexate therapy - PubMed
3 hours ago
- #immune dynamics
- #rheumatoid arthritis
- #methotrexate therapy
- MTX induces rapid immune remodeling in RA patients, detectable as early as 3 weeks after treatment initiation and preceding clinical improvement.
- The earliest and most pronounced changes occur in T follicular helper cells and plasmablasts, which decline in clinical responders but remain stable in non-responders, suggesting potential early biomarkers.
- Transcriptomic analyses identify novel regulatory hubs linked to MTX exposure, including LMNA, SCO2, GVQW3, and GIMAP family members.
- An interactive single-cell browser was developed to promote data accessibility for community-driven exploration.