Autoimmune diseases and risk of adverse pregnancy outcomes: a population-based cohort study of five million pregnancies in the UK - PubMed
3 hours ago
- #Population-based cohort
- #Adverse pregnancy outcomes
- #Autoimmune diseases
- Autoimmune diseases increase risks of adverse pregnancy outcomes.
- Marked risks: hyperemesis gravidarum (Addison's disease), miscarriage (Sjögren's syndrome), hypertension/pre-eclampsia (T1DM), gestational diabetes (Graves' disease).
- Obstetric risks: caesarean birth (IBD), small for gestational age (SLE), preterm birth (rheumatoid arthritis), stillbirth (SLE).
- Higher perinatal mental health issues: anxiety and depression notably in myasthenia gravis, SLE, multiple sclerosis.
- Some inverse associations: reduced hyperemesis in systemic sclerosis, SLE, myasthenia gravis; hypertensive disorders lower in MS.
- Study involved 5+ million UK pregnancies, using CPRD and HES data from 2000-2022.
- Findings highlight need for disease-specific pregnancy risk assessments.