NIR-II Imaging-Guided Phototherapy-Induced Senescence Reprograms Immunosuppressive Tumor Microenvironment for Potent Cancer Immunotherapy - PubMed
3 hours ago
- #phototherapy
- #immunotherapy
- #senescence
- NIR-II imaging-guided phototherapy induces cellular senescence in triple-negative breast cancer.
- A nanoplatform co-delivers a phototheranostic molecule and Aurora kinase inhibitor alisertib, released under 808 nm laser exposure.
- Induced senescence enhances immunostimulatory SASPs and reduces immunosuppressive cells in the tumor microenvironment.
- The approach activates cytotoxic T lymphocytes, depletes myeloid-derived suppressor cells and regulatory T cells, leading to tumor regression.
- It establishes durable immunological memory, preventing postoperative recurrence without systemic toxicity.