Nanoparticles isolated from the Gubi Zhitong formula alleviate knee osteoarthritis by reprogramming macrophages - PubMed
3 hours ago
- #Macrophage Reprogramming
- #Knee Osteoarthritis
- #Nanoparticles
- Nanoparticles isolated from the Gubi Zhitong formula (NPG) alleviate knee osteoarthritis (KOA) by reprogramming synovial macrophage polarization.
- NPG is rich in flavonoids and phenylpropanoids, forming stable nano-structures via hydrophobic interactions and hydrogen bonding.
- NPG improves joint function, reduces cartilage erosion, and mitigates synovial hyperplasia in KOA models.
- It suppresses M1-type pro-inflammatory cytokines and promotes M2-type anti-inflammatory factors, shifting macrophages from M1 to M2 phenotype.
- Mechanism involves dual activation of the aryl hydrocarbon receptor (AHR) through direct binding and modulation of the kynurenine pathway.
- Intra-articular injection of these TCM-based nanoparticles shows promise as a therapeutic strategy for KOA treatment.