Cell-Specific MicroRNA Networks Orchestrate the Pathogenesis of Alzheimer's Disease - PubMed
3 hours ago
- #Alzheimer's disease
- #Neurodegeneration
- #MicroRNAs
- Alzheimer's disease (AD) involves amyloid-beta plaques, tau tangles, synaptic dysfunction, and neuroinflammation.
- Multiple CNS cell types (neurons, astrocytes, microglia, oligodendrocytes, etc.) undergo cell-specific pathological changes.
- MicroRNAs (miRNAs) are key modulators dysregulated in AD, influencing amyloid/tau biology, synaptic function, glial activation, and more.
- miRNAs act across cell types via extracellular vesicle transfer, amplifying or mitigating AD-related processes.
- This review provides a cell-type-specific analysis of miRNAs in AD, covering roles in various CNS cells.
- Common miRNAs function across multiple cell types, and circulating/CSF miRNAs hold potential as biomarkers.
- Therapeutic strategies focus on restoring protective miRNAs or inhibiting pathogenic ones, with targeted interventions emphasized.