Integrated Genomic and Epigenomic Analysis Reveals Epigenetic Plasticity in Disease Progression and Multidrug Resistance in Multiple Myeloma - PubMed
5 hours ago
- #multiple myeloma
- #drug resistance
- #epigenetic plasticity
- The study used a cohort of nearly 900 patients from premalignant to late-stage refractory multiple myeloma, analyzed at molecular and clinical levels.
- Findings show that epigenetic dysregulation, driven by genomic events, plays a key role in disease progression and therapy resistance.
- Epigenetic plasticity allows myeloma cells to adapt, evade tumor microenvironment constraints, and develop multidrug resistance without new genomic alterations.
- Functional studies in a resistant cell line model indicated increased reliance on transcriptional cofactors, linking chromatin plasticity to therapy adaptation.
- The results suggest targeting epigenetic plasticity could be a therapeutic strategy in multiple myeloma's heterogeneous genetic background.