Induced pluripotent stem cell-derived dendritic cells potentiate the efficacy of interleukin-12-expressing oncolytic HSV-1 - PubMed
4 hours ago
- #dendritic cells
- #cancer immunotherapy
- #oncolytic virus
- Induced pluripotent stem cell-derived dendritic cells (iPSDCs) enhance the efficacy of interleukin-12-expressing oncolytic HSV-1 (T-mfIL12) in cancer immunotherapy.
- iPSDCs exhibit comparable functions to bone marrow-derived DCs, including antigen uptake, costimulatory molecule expression, and T cell stimulation in vitro and in vivo.
- In a murine bladder cancer model, iPSDCs combined with T-mfIL12 boosted immune responses, such as increased T cell infiltration and DC maturation, improving tumor control.
- This combination offers a scalable, standardized alternative to autologous DC therapy, presenting a clinically promising strategy for oncolytic virus-based treatments.