Gene regulatory mechanisms underlying sex- and age-dependent pathophysiology of MASLD - PubMed
2 hours ago
- #Gene Regulation
- #MASLD
- #Sex Differences
- MASLD is a prevalent chronic liver disease affecting about a quarter of adults globally, with its rise linked to obesity, sedentary lifestyles, Western diets, and aging.
- Early MASLD (simple steatosis) is reversible but can progress to MASH, involving inflammation, hepatocyte injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
- Liver gene expression changes between fed and fasted states to regulate energy homeostasis, influencing processes like gluconeogenesis, lipid storage, fatty acid oxidation, and detoxification.
- Sex differences in gene expression, driven by sex chromosome genes and hormones, significantly affect MASLD susceptibility and progression through metabolic and nutrient stress responses.
- The review covers sex- and age-dependent transcriptional regulation in the liver, using insights from animal models, human studies, and multi-omics data to inform therapeutic strategies for MASLD.