Tumor-derived GDF15 induces CCN3⁺ Schwann cells to promote cancer pain in pancreatic cancer - PubMed
2 hours ago
- #pancreatic cancer
- #Schwann cells
- #cancer pain
- A study identifies CCN3-positive Schwann cells as a key subpopulation in pancreatic ductal adenocarcinoma (PDAC) that promotes tumor innervation and contributes to cancer pain.
- Cancer cell-derived GDF15 drives the expansion of CCN3-positive Schwann cells and induces glycolytic reprogramming via the GFRAL receptor, activating the AKT-RUNX2 cascade and upregulating PFKM.
- Targeted inhibition of the GDF15-GFRAL signaling pathway in these Schwann cells significantly alleviates PDAC-associated pain, highlighting a potential therapeutic strategy.