Proteomic signatures of early retinal neurodegeneration in type 2 diabetes mellitus - PubMed
3 hours ago
- #Diabetic Retinopathy
- #Proteomics
- #Machine Learning
- Circulating plasma protein signatures identified for early diabetic retinal neurodegeneration (DRN) in type 2 diabetes.
- Proteomics-based model (Pro-DRN) developed with machine learning, enhancing risk prediction beyond clinical factors.
- Key proteins linked to inflammatory immune recruitment, extracellular matrix remodeling, and microvascular homeostasis.
- Pro-DRN achieved high performance (C-index 0.860 to 0.908) and improved discrimination and reclassification in validation.
- Model deployed as a web-based tool for early DRN screening and monitoring, validated across ethnic populations.