Dysregulated Proline Metabolism Exacerbates Hepatocellular Carcinoma Metastasis via EPRS1-Mediated mRNA Translation - PubMed
5 hours ago
- #hepatocellular carcinoma metastasis
- #EPRS1 translation
- #proline metabolism
- Proline metabolism is enhanced in hepatocellular carcinoma (HCC) metastasis, shown by increased proline levels and related enzymes in patients and mice.
- High proline levels promote HCC metastasis by binding to EPRS1 at residue Glu1123, selectively boosting translation of PIK3CA, AKT3, and ITGB1 mRNAs.
- The EPRS1 inhibitor bersiporocin blocks proline binding, suppresses protein translation, and inhibits metastasis in patient-derived xenograft models.