FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer's disease pathology - PubMed
3 hours ago
- #Alzheimer's disease
- #FAM134B
- #ER-phagy
- FAM134B acts as an ER-phagy receptor that degrades amyloid precursor protein (APP) via lysosomal pathways.
- Epigenetic silencing of FAM134B in Alzheimer's disease reduces ER-phagy, leading to APP accumulation and worsened pathology.
- Restoring FAM134B function in a mouse model improves APP clearance, reduces Aβ, and enhances cognitive and synaptic health.