Schizophrenia-associated glycoprotein Adamtsl3 regulates perineuronal net formation, maintenance, and adult cortical plasticity - PubMed
4 hours ago
- #Cortical Plasticity
- #Schizophrenia
- #Neuroscience
- Adamtsl3, a schizophrenia-associated glycoprotein, is a cell-autonomous regulator of perineuronal net (PNN) integrity in parvalbumin-positive (PV+) interneurons.
- Deletion of Adamtsl3, either postnatally or in adulthood, leads to PNN deficits by increasing MMP9 activity, reducing PNNs, decreasing Otx2 uptake, and raising oxidative stress in PV+ cells, which can be reversed with MMP9 inhibition.
- Conditional Adamtsl3 deletion in adult PV+ interneurons reactivated juvenile-like ocular dominance plasticity, highlighting its role in adult cortical plasticity and schizophrenia pathophysiology.