Single-cell and spatial transcriptomics identify immune-stromal interactions in cardiac allograft vasculopathy - PubMed
5 hours ago
- #cardiac allograft vasculopathy
- #spatial transcriptomics
- #interferon signaling
- Study integrates single-cell RNA sequencing and spatial transcriptomics to examine coronary arteries in cardiac allograft vasculopathy (CAV).
- Identifies a distinct transcriptional signature in CAV compared to atherosclerotic coronary artery disease and non-diseased controls.
- Reveals modulated vascular smooth muscle cells and macrophage subsets dominate the neointima and interact to promote type 1 interferon-mediated inflammation.
- Using a mouse model, shows that blocking interferon signaling with ruxolitinib reduces CAV incidence and prolongs allograft survival.
- Highlights IFN signaling as a potential therapeutic target for CAV, a major cause of mortality after heart transplantation.