CRISPR Tech Selectively Shreds Cancer Cells, Including "Undruggable" Cancers
5 hours ago
- #p53 Mutation
- #Cancer Therapy
- #CRISPR
- A new CRISPR-Cas12a2 technique selectively targets and destroys cancer cells with mutations in the p53 tumor suppressor gene, common in many cancers.
- The method initiates 'chromatin shredding' when it detects mutant RNA, triggering cell death without harming healthy cells, offering a precise alternative to traditional treatments.
- This programmable approach can be quickly adapted to target new mutations, potentially opening up therapies for difficult-to-treat cancers like ovarian, pancreatic, and lung cancer.