Carnitine deficiency alters fuel metabolism and voluntary wheel running in mice - PubMed

3 hours ago

Carnitine deficiency in mice was induced by mildronate treatment for 21 days, leading to a depletion of total carnitine in muscle (97%) and liver (90%).
Carnitine-deficient mice exhibited lower total energy expenditure, primarily due to reduced voluntary wheel running.
Fuel metabolism was altered: palmitate oxidation decreased, glucose oxidation increased, while octanoate oxidation remained unchanged.
Mitochondrial respiratory capacity was unaffected by carnitine deficiency.
Carnitine deficiency remodeled muscle and liver proteomes to support lipid oxidation and energy production.

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