SLC11A2 withholds divalent metals from Salmonella in the gut epithelium - PubMed
4 hours ago
- #Salmonella Infection
- #Nutritional Immunity
- #SLC11A2
- SLC11A2, a divalent metal transporter in intestinal epithelial cells, is recruited to Salmonella-containing vacuoles and restricts bacterial growth by withholding Fe2+ and possibly Mn2+.
- Salmonella experiences metal starvation (Fe2+, Zn2+, and potentially Mn2+) in host cells during early infection, contrasting with the metal-rich gut lumen.
- Knockout of SLC11A2 increases Salmonella proliferation in intestinal epithelial cells, indicating its role in nutritional immunity.
- Salmonella counters SLC11A2-mediated metal restriction using the MntH transporter and iron-binding siderophores, highlighting a host-pathogen tug-of-war for metals.
- SLC11A2-mediated sequestration of specific metals is identified as an innate defense mechanism in intestinal epithelial cells against Salmonella infection.