Global burden of fall-related injuries attributable to low bone mineral density in women aged 50-69 years: inequalities, projections to 2050, and Mendelian randomisation - PubMed
4 hours ago
- #global health
- #osteoporosis
- #women's health
- The study examines the global burden of fall-related injuries due to low bone mineral density (LBMD) in women aged 50-69.
- It uses GBD 2021 data from 1990-2021 and projections to 2050, along with Mendelian randomization analysis.
- Age-standardized DALY and YLD rates declined slightly, but absolute DALYs nearly doubled and YLDs increased significantly.
- Women had 35-45% higher age-standardized disability rates and about 75% more YLDs than men in the same age group.
- Inequalities in burden were substantial, with projections indicating continued growth in absolute disability despite falling age-standardized rates.
- Mendelian randomization found no clear link between genetically predicted lower bone density and falls, but a higher risk of femoral fractures.
- LBMD contributes more to fracture susceptibility and post-fall disability than to fall occurrence, emphasizing need for early osteoporosis assessment and prevention strategies.