Repurposing Citicoline for single prolonged stress-induced behavioral and hippocampal molecular abnormalities in male mice: Novel mechanistic attenuation of endoplasmic reticulum stress, mitochondrial
3 hours ago
- #Mitophagy
- #Citicoline
- #PTSD
- The study investigated repurposing citicoline for PTSD-like symptoms in male mice exposed to single prolonged stress (SPS).
- Citicoline reversed SPS-induced behavioral deficits in social novelty preference, marble burying, and cue-induced freezing.
- Molecularly, citicoline attenuated endoplasmic reticulum stress by modulating unfolded protein response components (e.g., reducing phosphorylated PERK, ATF4, ATF6).
- It enhanced protective mitophagy via increased PTEN-induced kinase 1 and parkin expression, aiding clearance of damaged mitochondria and reactive oxygen species.
- Citicoline reduced oxidative stress by lowering lipid peroxidation and restoring glutathione levels.
- It promoted mitochondrial biogenesis via upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha and inhibited apoptosis by suppressing caspase-3.