Integrative omics identify NID2 as a therapeutic target linking depression and colorectal cancer in humans - PubMed
3 hours ago
- #depression
- #colorectal cancer
- #omics
- Depression is linked to an increased prevalence of colorectal precancerous lesions and cancer risk.
- Mendelian randomization suggests a causal effect of depression on colorectal tumorigenesis.
- Nidogen-2 (NID2) is identified as a causal mediator through integrative omics analyses.
- NID2 levels are reduced in plasma and colorectal tissues in individuals with depression.
- NID2 serves as a biomarker and therapeutic target linking depression and colorectal cancer.