The role and mechanism of ZBP1 in the occurrence and development of systemic inflammation - PubMed
5 hours ago
- #therapeutic target
- #ZBP1
- #systemic inflammation
- ZBP1 acts as a critical initiator of PANoptosis and sensor of Z-nucleic acids, involved in various inflammatory diseases.
- In the nervous system, ZBP1 exacerbates brain injury and neuroinflammation via RIPK3-MLKL-dependent necroptosis.
- In digestive diseases, it contributes to periodontal disease and non-alcoholic steatohepatitis by regulating pyroptosis and inflammation.
- In musculoskeletal system, ZBP1 accelerates osteoarthritis progression by facilitating chondrocyte damage and inflammation.
- In circulatory system, it mitigates myocarditis and heart failure by inhibiting RIPK3 and NF-κB pathways.
- In endocrine system, ZBP1 is implicated in type 2 diabetes by regulating inflammatory responses and insulin resistance.
- In respiratory system, it mediates cell death and inflammation via ZBP1-RIPK3-MLKL pathway in asthma, ARDS, and COVID-19.
- In immune system, ZBP1 aggravates systemic lupus erythematosus and rheumatoid arthritis by triggering inflammatory cell death.
- ZBP1 plays a pivotal role in systemic inflammation through multiple cell death and inflammatory signaling pathways, offering insights for therapeutic strategies.