Characterization of the virus-host RNA-RNA interactome across important human pathogenic RNA viruses - PubMed
2 days ago
- #RNA-RNA interactome
- #host-pathogen interaction
- #viral pathogenesis
- Systematic mapping of virus-host RNA-RNA interactions using optimized RNA antisense purification (RAP-RNA).
- Applied to three human RNA viruses: hepatitis C virus (HCV), yellow fever virus (YFV), and chikungunya virus (CHIKV).
- Identified interactions with host mRNAs (translation/proteasome factors), mtRNAs, snoRNAs, and snRNAs.
- Most interactions appear non-critical for viral infection but may stabilize host RNAs.
- Guides future research on viral RNA regulation and host factor exploitation.