Microbiota and metabolites modulation of cancer stem cells and chemotherapy sensitivity - PubMed
4 hours ago
- #Chemoresistance
- #Cancer Stem Cells
- #Microbiota
- Microbiota and their metabolites influence cancer stem cells (CSCs), which drive tumor initiation, metastasis, and therapy resistance.
- Mechanisms include modulation of the CSC niche through stromal cells, extracellular matrix, and soluble factors.
- Targeting microbiota or metabolites (e.g., via probiotics, antibiotics, nanomedicine) may disrupt CSCs and improve chemotherapy sensitivity.