No overall increased risk of death in individuals with sickle cell trait: a study of 467 779 general population adults - PubMed
3 hours ago
- #Mortality risk
- #Health outcomes
- #Sickle cell trait
- Sickle cell trait (SCT) carriers do not have an increased overall risk of all-cause death compared to non-carriers.
- SCT carriers are not at increased risk for cardiovascular death, myocardial infarction, ischemic stroke, pulmonary embolism, or heart failure.
- SCT carriers have an increased risk of diabetes, chronic kidney disease, and hypertension.
- SCT carriers with diabetes have a higher risk of cardiovascular death compared to non-carriers with diabetes.
- Hospital registry-based SCT diagnoses may show increased risks due to selection bias, not inherent to SCT itself.