Efficacy of Prophylactic Tranexamic Acid Use After Vaginal Delivery According to Postpartum Hemorrhage Risk: Randomized, Double-Blind, Placebo-Controlled Trial - PubMed
3 hours ago
- #postpartum hemorrhage
- #vaginal delivery
- #tranexamic acid
- The study evaluated prophylactic intravenous tranexamic acid (TA) after vaginal delivery to reduce postpartum blood loss.
- It involved 480 women stratified into low- and high-risk postpartum hemorrhage (PPH) groups, with each group randomized to TA or placebo.
- TA significantly reduced collected blood volume and estimated blood loss in both low- and high-risk groups compared to placebo.
- In high-risk patients, TA also lowered the incidence of uterine atony and reduced the need for blood transfusion and additional uterotonics.
- No clinically significant adverse effects or differences in laboratory safety parameters like D-dimer were observed.
- The study concluded that TA is effective and well-tolerated in reducing postpartum blood loss, with added benefits in high-risk patients.