Primary Results of the SALAMANDER Registry: A Multicenter Observational Cohort Study - PubMed
3 days ago
- #left atrial appendage occlusion
- #anticoagulation
- #atrial fibrillation
- The SALAMANDER registry is a multicenter observational cohort study evaluating left atrial appendage occlusion (LAAO) for thromboembolism prevention in nonvalvular atrial fibrillation.
- Enrolled 1,660 patients with a median age of 76 and a median CHA₂DS₂-VASc score of 4; the most common indication was significant bleeding (83.7%), primarily during direct oral anticoagulant use.
- Technical success rate was 95.5%, with residual leak and tamponade as main causes of failure; procedural success was 90.5%, limited by vascular complications, periprocedural death, and major bleeding.
- Success rates did not differ significantly between devices, indicating comparable safety and efficacy across contemporary LAAO devices.
- Postprocedural therapy most often included dual antiplatelet therapy (50%), with all patients requiring some pharmacological treatment after LAAO.