Comparative Effects of Antidiabetic Drugs on Body Composition: A Systematic Review and Network Meta-Analysis - PubMed
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- #Body Composition
- #Antidiabetic Drugs
- #Systematic Review
- Tirzepatide, a dual GIP/GLP-1 receptor agonist, showed the greatest reduction in fat mass compared to placebo.
- GLP-1 agonists like semaglutide and liraglutide moderately reduced fat mass, while insulin glargine and alogliptin were linked to fat mass gain.
- Tirzepatide and liraglutide were associated with significant reductions in lean body mass, whereas SGLT2 inhibitors caused minor losses.
- Metformin, insulin regimens, and DPP4 inhibitors had neutral effects on lean body mass.
- Exercise mitigated the lean body mass loss associated with liraglutide.
- The systematic review and network meta-analysis included 41 trials with 2906 participants, analyzing the effects of antidiabetic drugs on body composition.