IL17 signaling promotes oocyte developmental competence acquisition during maturation - PubMed
3 hours ago
- #IL17 signaling
- #oocyte maturation
- #developmental competence
- Interleukin 17D (IL17D) is identified as a key follicular fluid protein upregulated during oocyte maturation, promoting competence acquisition.
- IL17D enhances oocyte-cumulus cell communication via increased CX43 and transzonal projections, maintaining redox homeostasis and nuclear-cytoplasmic synchrony.
- IL17D treatment improves embryo development by modulating lipid metabolism and histone modifications, acting through IL17 signaling via CD93 binding.
- IL17A and IL17F also boost oocyte maturation quality, with IL17D's function conserved across pig and mouse models.