GLUL pitches in thrombocytopoiesis by restricting ammonia accumulation during megakaryocyte maturation - PubMed
3 hours ago
- #GLUL
- #Thrombocytopoiesis
- #Megakaryocyte Maturation
- Glutamine synthetase (GLUL) is critical for megakaryocyte maturation and platelet production by limiting ammonia buildup.
- GLUL expression increases during polyploidization in megakaryocytes, and its deficiency leads to impaired maturation and platelet production.
- Ammonia accumulation results from ADAR1-mediated dsRNA editing; without GLUL detoxification, it causes lysosomal and mitochondrial damage and cell death.
- The compound Fulvotomentoside A (FtA) acts as a GLUL agonist and can promote thrombocytopoiesis after radiation and chemotherapy injury in mice.