DUSP4-mediated dephosphorylation of PSMD14 enhances PSMD14-dependent deubiquitination of MICALL2 and promotes malignant progression in clear cell renal cell carcinoma - PubMed
3 hours ago
- #oncogenic signaling
- #renal cell carcinoma
- #deubiquitination
- PSMD14 is upregulated in clear cell renal cell carcinoma (ccRCC) and associated with poor patient outcomes.
- Knockdown of PSMD14 inhibits ccRCC cell proliferation, migration, and invasion, both in vitro and in vivo.
- PSMD14 suppresses ubiquitination and degradation of MICALL2, leading to increased MICALL2 expression and promoting ccRCC progression.
- DUSP4 dephosphorylates PSMD14, enhancing its interaction with MICALL2 and amplifying its oncogenic effects.
- The DUSP4-PSMD14-MICALL2 axis provides potential therapeutic targets for ccRCC treatment.