Lung microbiota-derived deoxyinosine alleviates TBI-aggravated sepsis-induced lung injury via the S100A9/RAGE pathway - PubMed
3 hours ago
- #S100A9/RAGE pathway
- #brain-lung axis
- #lung microbiota
- Traumatic brain injury (TBI) exacerbates sepsis-induced lung injury by disrupting the lung microbiota, reducing Corynebacterium and deoxyinosine levels.
- Deoxyinosine administration alleviates lung injury by shifting alveolar macrophages from M1 to M2 phenotype and inhibiting the S100A9/RAGE pathway.
- The study identifies a brain-lung axis mediated by microbiota-derived deoxyinosine, offering potential therapeutic targets for post-TBI complications.