β-Arrestin condensates regulate G-protein-coupled receptor function - PubMed
3 hours ago
- #GPCR
- #Phase Separation
- #β-Arrestin
- β-Arrestins 1 and 2 are multifunctional adaptor proteins that regulate G-protein-coupled receptor (GPCR) signaling.
- β-Arrestins undergo liquid-liquid phase separation, forming condensates that regulate GPCR functions.
- The condensation is specific to visual arrestins and β-arrestins, with oligomerization occurring near GPCRs.
- β-Arrestin condensates regulate GPCR functions such as internalization and signaling.
- Liquid-liquid phase separation serves as a promoter of signaling compartmentalization at GPCRs.