A Bioinspired Three-Dimensional High-Curvature Nano-Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning-Assisted Prostate Cancer Precision Diagnosis
2 hours ago
- #microfluidics
- #cancer diagnosis
- #extracellular vesicles
- Development of a bioinspired microfluidic chip with a 3D high-curvature TiO2 nano-interface for efficient and rapid enrichment of small extracellular vesicles (sEVs).
- Integration of biotin-modified artificial insertion peptide (BAIP) and herringbone mixing achieves >90% capture efficiency within 5 minutes, with redox-responsive release for intact sEV analysis.
- Application to prostate cancer patient plasma reveals 110 differentially expressed sEV proteins, enabling mRNA quantification and machine learning-assisted diagnosis with 80% accuracy.