Sex-Specific Regulation of the Turandot Gene Family Modulates Temperature-Dependent Lifespan in Drosophila melanogaster - PubMed
3 hours ago
- #Gene Regulation
- #Thermal Stress
- #Aging
- Temperature significantly influences lifespan across animals, but the molecular mechanisms linking thermal cues to aging are not well understood.
- Transcriptomic and metabolomic analyses in Drosophila reveal that thermal stress leads to rapid and profound transcriptome remodeling, surpassing metabolic adaptation.
- The Turandot (tot) gene family is identified as a key player in the thermal longevity response, actively regulating lifespan rather than just responding to temperature.
- Knockdown of tot genes via RNAi extends lifespan across various temperatures, separating the longevity benefit from the thermal environment.
- This lifespan extension shows distinct sexual dimorphism, indicating sex-specific strategies in stress response and resource allocation.
- The findings position the Turandot family as a novel and genetically separable regulator of aging, challenging the idea that temperature effects on lifespan are purely passive.