Immune Privilege of the Eye: A Delicate Balance Between Clarity and Chaos - PubMed
3 hours ago
- #ocular disease
- #inflammation
- #immune privilege
- Ocular immune privilege maintains a balance to prevent inflammation and preserve vision through mechanisms like anatomical barriers and immunomodulatory mediators.
- Disruption of ocular immune privilege, not complete loss, contributes to diseases such as uveitis, diabetic retinopathy, and corneal transplantation issues.
- Diseases involve altered immune homeostasis, increased inflammation, impaired barriers, and reduced local immune restraint, varying by ocular compartment.
- Immune privilege is dynamic and conditional, explaining why pathologies like tumors and allergies behave uniquely in ocular tissues.
- Understanding preserved or lost immune elements can enhance ocular pathology insights and guide targeted immune therapies.