Chaperone-mediated autophagy is a tumor-suppressive mechanism in hepatocellular carcinoma - PubMed
3 hours ago
- #hepatocellular carcinoma
- #chaperone-mediated autophagy
- #tumor suppression
- Chaperone-mediated autophagy (CMA) is a tumor-suppressive mechanism in hepatocellular carcinoma (HCC) with cell-type-specific functions.
- Loss of CMA in hepatocytes promotes early malignant transformation, while in T cells it impairs early immune control but supports later tumor growth.
- CMA decline with aging and metabolic disease is linked to HCC, and the study uses mouse models with LAMP2A deletion in various cell types.
- Proteomic profiling identifies STAG2, a cohesin complex component, as a CMA substrate that accumulates in CMA-dysregulated hepatocytes and drives cell cycle dysregulation.
- STAG2 accumulation is validated in human HCC tissues, highlighting its role in hepatocarcinogenesis and potential therapeutic relevance.
- The findings position CMA as a dual hepatocyte- and immune-dependent suppressor of liver tumorigenesis.