Three-dimensional micro-CT analysis of vascular remodeling and vascular pruning in pulmonary arterial hypertension - PubMed
3 hours ago
- #pulmonary arterial hypertension
- #vascular remodeling
- #micro-CT
- Micro-CT analysis revealed a 50% reduction in acinar arterial lumen diameter in end-stage PAH lungs.
- There was a 61% decrease in the number of intra-acinar arterioles, confirming vascular pruning.
- Arterial narrowing correlated with pulmonary vascular resistance and mean pulmonary artery pressure.
- Heritable PAH had more plexiform lesions, located more distally at the acinar level, than idiopathic PAH.
- Vascular rarefaction may initiate remodeling, not just result from it, influencing PAH severity.