Spatial characterization of skin lesions in discoid and systemic lupus erythematosus - PubMed
2 hours ago
- #Spatial Transcriptomics
- #Skin Lesions
- #Lupus Erythematosus
- Spatial transcriptomic atlas constructed using Stereo-seq for discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) skin lesions.
- Stress keratinocytes at epidermis-dermis interface recruit T and plasma cells via IFN-γ-JAK-STAT axis and CXCL9/10/11-CXCR3 signaling, more active in SLE than DLE.
- Immune cell niches resembling tertiary lymphoid structures (TLS) found in chronic DLE and SLE lesions, with coordinated infiltration of various B, T, and endothelial cells.