GLI1 activation induced by intermittent hypoxia drives cardiac fibroblast activation via enhanced PKM2-mediated glycolysis - PubMed
3 hours ago
- #cardiac fibrosis
- #intermittent hypoxia
- #GLI1
- Intermittent hypoxia (IH) activates the Hedgehog signaling pathway in cardiac fibroblasts, leading to GLI1 nuclear translocation.
- GLI1 overexpression induces cardiac fibroblast activation and fibrosis, while its inhibition attenuates IH-induced fibrosis and cardiac dysfunction.
- GLI1 directly upregulates PKM2 transcription, which enhances glycolysis in cardiac fibroblasts, promoting fibrosis.
- Elevated plasma lactate levels in patients with obstructive sleep apnea correlate with a higher incidence of heart failure events.