Single-cell transcriptomic comparison of tubular segment maturation in advanced human in vitro kidney models - PubMed
4 hours ago
- #Transcriptomics
- #Kidney models
- #Organoids
- Advanced human in vitro kidney models include (i)PSC-derived organoids, tissue/urine-derived tubuloids, and iPSC organoid-derived tubuloids (iPSCod tubuloids).
- Transcriptomic comparison reveals distinct profiles, diverse adaptive cell states, and maturation marker differences across models compared to in vivo adult and fetal profiles.
- The study provides insights into model characteristics and guidance for researchers in selecting appropriate kidney models for various applications.