Simultaneous or Sequential Treatment of IgA Nephropathy - Specific Disease Drivers and Non-specific Consequences of Nephron Loss? - PubMed
3 days ago
- #treatment strategy
- #nephron loss
- #IgA nephropathy treatment
- Treatment of IgA nephropathy involves a strategic dilemma: simultaneous targeting of disease drivers and consequences of nephron loss vs. sequential stepwise therapy addition.
- Early combined treatment proponents argue that delaying immunosuppression after maximizing supportive care causes harm due to ongoing immune activity and irreversible damage.
- Sequential strategy advocates emphasize disease heterogeneity, polypharmacy risks, and individualized escalation based on dynamic risk assessment.
- Future treatment algorithms may integrate risk stratification, biomarkers, and patient preferences to balance early control with overtreatment risks.