Nerandomilast attenuates Pantoea agglomerans-induced hypersensitivity pneumonitis by regulating M1 macrophage polarization and fibroblast activation - PubMed
3 days ago
- #Nerandomilast
- #Hypersensitivity Pneumonitis
- #Macrophage Polarization
- Nerandomilast, a novel PDE4B inhibitor, reduces hypersensitivity pneumonitis (HP) caused by Pantoea agglomerans.
- In vitro, it inhibits M1 macrophage proinflammatory markers via CREB phosphorylation and NF-κB suppression.
- Nerandomilast blocks TGFβ1-induced fibroblast activation by inhibiting Smad and non-Smad pathways.
- In vivo, it decreases inflammatory cells, cytokines, oxidative stress, and pulmonary fibrosis in HP mice.
- The findings suggest nerandomilast as a potential clinical treatment for HP by modulating macrophage polarization and fibroblast activity.