Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization - PubMed
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- #metabolic plasticity
- #redox homeostasis
- #metastasis
- Cancer cells reprogram metabolism to adapt during tumor growth and metastasis.
- EMT and transcription factor ZEB1 drive metastasis, often upregulated in tumors.
- Murine PDAC cell lines with different EMT states and ZEB1 expression used.
- Epithelial-type KPCepi cells efficiently colonize lungs due to metabolic plasticity.
- ZEB1-deficient KPCZ cells have poor colonization, glycolytic reserve issues, mitochondrial dysfunction, and low antioxidants.
- Mesenchymal-type KPCmes cells also colonize poorly despite normal glycolysis and functional mitochondria, but have low detoxifying metabolites.
- Low metastatic capacity correlates with ferroptosis susceptibility and inability to handle reactive oxygen species.
- Metabolic plasticity and redox homeostasis are essential for lung colonization.
- Targeting metabolic adaptability and redox buffering may prevent PDAC metastasis.