Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release - PubMed
2 hours ago
- #Inflammation
- #Inflammasome
- #Mitochondrial Calcium
- Mitochondrial Ca2+ uptake via the MCU drives mitochondrial fragmentation.
- This fragmentation is required for NLRP3 inflammasome-mediated IL-1β release in macrophages.
- MCU deficiency reduces IL-1β secretion and inflammation in a disease model.
- MCU is identified as a potential therapeutic target for inflammatory diseases.