Addition of blood-stage antibody enhances anti-sporozoite antibody protection in a humanized mouse model of Plasmodium falciparum infection - PubMed
3 hours ago
- #malaria vaccine
- #Plasmodium falciparum
- #monoclonal antibodies
- Anti-CSP monoclonal antibodies lose protection when serum concentration falls below approximately 30 μg/mL and plateau above about 60 μg/mL.
- Breakthrough infections in the presence of anti-CSP mAbs result in significantly fewer parasites emerging from the liver.
- Adding an anti-RH5 blood-stage monoclonal antibody to a partially protective anti-CSP mAb provides additional benefits by controlling blood-stage parasitemia, leading to only transient, low-level infections.
- The study offers proof-of-concept that multi-stage antibodies (targeting both sporozoite and blood stages) may offer superior protection compared to single-stage approaches.