Efficacy and safety of RTS, S and R21 malaria vaccines in children under five in Africa: a systematic review and meta-analysis of randomized controlled trials - PubMed
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- #systematic review
- #pediatric health
- #malaria vaccines
- RTS,S vaccine efficacy: 32% against first clinical malaria, 29% against multiple episodes, 17-22% against severe malaria.
- R21 vaccine efficacy: 68% against first episodes, 67% against multiple episodes in a single Phase 3 trial.
- Safety profiles: RTS,S pooled SAE incidence 11.2%, R21 pooled SAE incidence 3%, with no vaccine-attributable deaths.
- Both vaccines show acceptable reactogenicity and safety, but continued pharmacovigilance is essential.