Metabolic and inflammatory biomarker trajectories after a cancer diagnosis and the risk of cardiovascular diseases - PubMed

3 hours ago

Cancer patients have an increased risk of cardiovascular diseases (CVD), but there is limited evidence on stratifying them for CVD risk.
A cohort study (1985-2020) examined biomarker trajectories after cancer diagnosis and their link to subsequent CVD risk.
Using latent class growth modelling, trajectories were identified for 11 biomarkers post-cancer diagnosis.
Cancer patients with initially high and subsequently increasing glucose levels had a 110% higher CVD risk compared to those with low-stable levels.
Low-stable albumin levels, even within normal range, were associated with elevated CVD risk.
Patients with initially low-stable but subsequently increasing uric acid levels showed a 20% reduced CVD risk.
Findings suggest specific trajectories of glucose, albumin, and uric acid are associated with CVD risk in cancer patients.
Further research is needed to elucidate biological mechanisms and validate these associations for improved CVD prevention.

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