Understanding resistance in glioblastoma: insights into personalized and targeted therapeutic strategies - PubMed
4 hours ago
- #chemoresistance
- #personalized therapy
- #glioblastoma
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis despite combined treatments, including surgery, radiation, and chemotherapy.
- Resistance mechanisms in GBM involve DNA repair pathways like O6-methylguanine-DNA methyltransferase, base excision repair, and homologous recombination, which resolve therapy-induced DNA lesions.
- Other factors contributing to resistance include oncogenic mutations, glioma stem cells (GSCs), metabolic reprogramming promoting immune evasion, and the blood-brain barrier limiting drug delivery.
- Emerging therapeutic targets exploit synthetic lethality, and personalized strategies like CAR-T cell therapy and cancer vaccines show promise for improving survival in different GBM subtypes.
- Advances in multi-omics profiling and machine learning enable tailored immunotherapies, but translation is hindered by heterogeneity, limited patient availability, and trial disparities.